Stepwise modifications of transcriptional hubs link pioneer factor activity to a burst of transcription

Abstract Binding of transcription factors (TFs) promotes the subsequent recruitment of coactivators and preinitiation complexes to initiate eukaryotic transcription, but this time course is usually not visualized. It is commonly assumed that recruited factors eventually co-reside in a higher-order s...

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Bibliographic Details
Main Authors: Chun-Yi Cho, Patrick H. O’Farrell
Format: Article
Language:English
Published: Nature Portfolio 2023-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-40485-6