Mechanism underlying hippocampal long-term potentiation and depression based on competition between endocytosis and exocytosis of AMPA receptors

Abstract N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP) and long-term depression (LTD) of signal transmission form neural circuits and thus are thought to underlie learning and memory. These mechanisms are mediated by AMPA receptor (AMPAR) trafficking in postsynaptic neu...

Full description

Bibliographic Details
Main Authors: Tomonari Sumi, Kouji Harada
Format: Article
Language:English
Published: Nature Portfolio 2020-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-020-71528-3