Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway

Berberine Ameliorates Subarachnoid Hemorrhage Injury via Induction of Sirtuin 1 and Inhibiting HMGB1/Nf-κB Pathway

Excessive cerebral inflammation plays a key role in early brain injury (EBI) after subarachnoid hemorrhage (SAH). Berberine, an isoquinoline alkaloid isolated from Chinese herb Coptis chinensis, possesses anti-inflammatory, and neuroprotective effects. Here we evaluated the beneficial effects of ber...

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Bibliographic Details
Main Authors: Xiang-Hua Zhang, Lei Peng, Jing Zhang, Yi-Peng Dong, Cheng-Jun Wang, Cang Liu, Da-Yong Xia, Xiang-Sheng Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
subarachnoid hemorrhage
inflammation
berberine
HMGB1
Sirtuin 1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01073/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.01073/full

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