Targeting <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines

Targeting <named-content content-type="genus-species">Mycobacterium tuberculosis</named-content> Tumor Necrosis Factor Alpha-Downregulating Genes for the Development of Antituberculous Vaccines

ABSTRACT Tumor necrosis factor alpha (TNF) plays a critical role in the control of Mycobacterium tuberculosis, in part by augmenting T cell responses through promoting macrophage phagolysosomal fusion (thereby optimizing CD4+ T cell immunity by enhancing antigen presentation) and apoptosis (a proces...

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Bibliographic Details
Main Authors: Aaron Olsen, Yong Chen, Qingzhou Ji, Guofeng Zhu, Aruna Dharshan De Silva, Catherine Vilchèze, Torin Weisbrod, Weimin Li, Jiayong Xu, Michelle Larsen, Jinghang Zhang, Steven A. Porcelli, William R. Jacobs, John Chan
Format: Article
Language:English
Published: American Society for Microbiology 2016-07-01
Series:mBio
Online Access:https://journals.asm.org/doi/10.1128/mBio.01023-15

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https://journals.asm.org/doi/10.1128/mBio.01023-15

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