Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration

Lysosomal acidification dysfunction in microglia: an emerging pathogenic mechanism of neuroinflammation and neurodegeneration

Abstract Microglia are the resident innate immune cells in the brain with a major role in orchestrating immune responses. They also provide a frontline of host defense in the central nervous system (CNS) through their active phagocytic capability. Being a professional phagocyte, microglia participat...

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Bibliographic Details
Main Authors: Joseph D. Quick, Cristian Silva, Jia Hui Wong, Kah Leong Lim, Richard Reynolds, Anna M. Barron, Jialiu Zeng, Chih Hung Lo
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Neuroinflammation
Subjects:
Lysosomal acidification
Autophagy
Phagocytosis
Cytokines
Toxic protein aggregates
Neuroinflammation
Online Access:https://doi.org/10.1186/s12974-023-02866-y

Internet

https://doi.org/10.1186/s12974-023-02866-y

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