Maximum depth sequencing reveals an ON/OFF replication slippage switch and apparent in vivo selection for bifidobacterial pilus expression

Maximum depth sequencing reveals an ON/OFF replication slippage switch and apparent in vivo selection for bifidobacterial pilus expression

Abstract The human gut microbiome, of which the genus Bifidobacterium is a prevalent and abundant member, is thought to sustain and enhance human health. Several surface-exposed structures, including so-called sortase-dependent pili, represent important bifidobacterial gut colonization factors. Here...

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Bibliographic Details
Main Authors: Christophe Penno, Mary O’Connell Motherway, Yuan Fu, Virag Sharma, Fiona Crispie, Paul D. Cotter, Benoit Houeix, Lokesh Joshi, Francesca Bottacini, Aoife O’Dwyer, Gary Loughran, John F. Atkins, Douwe van Sinderen
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-13668-2

Internet

https://doi.org/10.1038/s41598-022-13668-2

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