PACAP-38 Induces Transcriptomic Changes in Rat Trigeminal Ganglion Cells Related to Neuroinflammation and Altered Mitochondrial Function Presumably via PAC1/VPAC2 Receptor-Independent Mechanism

PACAP-38 Induces Transcriptomic Changes in Rat Trigeminal Ganglion Cells Related to Neuroinflammation and Altered Mitochondrial Function Presumably via PAC1/VPAC2 Receptor-Independent Mechanism

Pituitary adenylate cyclase-activating polypeptide (PACAP) is a broadly expressed neuropeptide which has diverse effects in both the peripheral and central nervous systems. While its neuroprotective effects have been shown in a variety of disease models, both animal and human data support the role o...

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Bibliographic Details
Main Authors: Krisztina Takács-Lovász, József Kun, Timea Aczél, Péter Urbán, Attila Gyenesei, Kata Bölcskei, Éva Szőke, Zsuzsanna Helyes
Format: Article
Language:English
Published: MDPI AG 2022-02-01
Series:International Journal of Molecular Sciences
Subjects:
pituitary adenylated cyclase-activating polypeptide (PACAP)
trigeminal ganglion
transcriptomics
intracellular calcium
mitochondrial electron transport chain
Online Access:https://www.mdpi.com/1422-0067/23/4/2120

Internet

https://www.mdpi.com/1422-0067/23/4/2120

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