Genetic partitioning of interleukin‐6 signalling in mice dissociates Stat3 from Smad3‐mediated lung fibrosis

Genetic partitioning of interleukin‐6 signalling in mice dissociates Stat3 from Smad3‐mediated lung fibrosis

Abstract Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis. While inflammatory cytokines, including interleukin (IL)‐6, are elevated in IPF, the molecular mechanisms that underli...

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Bibliographic Details
Main Authors: Robert J. J. O'Donoghue, Darryl A. Knight, Carl D. Richards, Cecilia M. Prêle, Hui Ling Lau, Andrew G. Jarnicki, Jessica Jones, Steven Bozinovski, Ross Vlahos, Stefan Thiem, Brent S. McKenzie, Bo Wang, Philip Stumbles, Geoffrey J. Laurent, Robin J. McAnulty, Stefan Rose‐John, Hong Jian Zhu, Gary P. Anderson, Matthias R. Ernst, Steven E. Mutsaers
Format: Article
Language:English
Published: Springer Nature 2012-06-01
Series:EMBO Molecular Medicine
Subjects:
interleukin 6
pulmonary fibrosis
Smad3
Stat3
transforming growth factor beta
Online Access:https://doi.org/10.1002/emmm.201100604

Internet

https://doi.org/10.1002/emmm.201100604

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