The effects of sildenafil in maternal and fetal outcomes in pregnancy: A systematic review and meta-analysis.

<h4>Background</h4>The number of studies associating the use of sildenafil in gestation is increasing. This drug inhibits phosphodiesterase type 5 (PDE5), an enzyme responsible for degradation of nitric oxide, and its efficacy is greater in the placental territory, as the maternal side o...

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Bibliographic Details
Main Authors: Raquel Domingues da Silva Ferreira, Romulo Negrini, Wanderley Marques Bernardo, Ricardo Simões, Sebastião Piato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0219732