Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation

Macrophage mediated recognition and clearance of Borrelia burgdorferi elicits MyD88-dependent and -independent phagosomal signals that contribute to phagocytosis and inflammation

Abstract Background Macrophages play prominent roles in bacteria recognition and clearance, including Borrelia burgdorferi (Bb), the Lyme disease spirochete. To elucidate mechanisms by which MyD88/TLR signaling enhances clearance of Bb by macrophages, we studied wildtype (WT) and MyD88−/− Bb-stimula...

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Bibliographic Details
Main Authors: Sarah J. Benjamin, Kelly L. Hawley, Paola Vera-Licona, Carson J. La Vake, Jorge L. Cervantes, Yijun Ruan, Justin D. Radolf, Juan C. Salazar
Format: Article
Language:English
Published: BMC 2021-05-01
Series:BMC Immunology
Subjects:
Macrophage
Phagocytosis
Inflammation
Borrelia
MyD88
Online Access:https://doi.org/10.1186/s12865-021-00418-8

Internet

https://doi.org/10.1186/s12865-021-00418-8

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