Diosmin alleviates doxorubicin-induced chemobrain in rats via inhibition of oxido-inflammation, apoptosis and modulation of autophagy

Diosmin alleviates doxorubicin-induced chemobrain in rats via inhibition of oxido-inflammation, apoptosis and modulation of autophagy

Background/aim: Doxorubicin (DOX) is a highly effective chemotherapy medicine commonly used to treat breast cancer; yet, despite its clinical efficacy, it usually causes chemobrain. As a result, we investigated the neuroprotective effects of Diosmin (DIOS) on DOX-induced chemobrain in male rat brain...

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Bibliographic Details
Main Authors: Oyovwi O. Mega, Falajiki Y. Faith, Ohwin P. Ejiro, Joseph G. Uchechukwu, Olowe G. Temitope, Onome B. Oghenetega, Emojevwe Victor, Tesi P. Edesiri, Rotu A. Rume, Rotu A. Rotu, Oyeleke Abiodun Abioye, Okwute Patrick Godwin
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Brain Disorders
Subjects:
Chemobrain
Diosmin
Doxorubicin
Inflammation
Oxidative stress
Autophagic flux
Online Access:http://www.sciencedirect.com/science/article/pii/S2666459323000483

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http://www.sciencedirect.com/science/article/pii/S2666459323000483

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