Genome-Wide Survey for Microdeletions or -Duplications in 155 Patients with Lower Urinary Tract Obstructions (LUTO)

Genome-Wide Survey for Microdeletions or -Duplications in 155 Patients with Lower Urinary Tract Obstructions (LUTO)

Lower urinary tract obstruction (LUTO) is, in most cases, caused by anatomical blockage of the bladder outlet. The most common form are posterior urethral valves (PUVs), a male-limited phenotype. Here, we surveyed the genome of 155 LUTO patients to identify disease-causing CNVs. Raw intensity data w...

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Bibliographic Details
Main Authors: Luca M. Schierbaum, Sophia Schneider, Stefan Herms, Sugirthan Sivalingam, Julia Fabian, Heiko Reutter, Stefanie Weber, Waltraut M. Merz, Marcin Tkaczyk, Monika Miklaszewska, Przemyslaw Sikora, Agnieszka Szmigielska, Grazyna Krzemien, Katarzyna Zachwieja, Maria Szczepanska, Katarzyna Taranta-Janusz, Pawel Kroll, Marcin Polok, Marcin Zaniew, Alina C. Hilger
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Genes
Subjects:
lower urinary tract obstruction (LUTO)
posterior urethral valves
male limited phenotype
de novo
copy number variations (CNVs)
maternal transmission
Online Access:https://www.mdpi.com/2073-4425/12/9/1449

Internet

https://www.mdpi.com/2073-4425/12/9/1449

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