Enhanced Tumor Targeting and Antitumor Activity of Methylated β-Cyclodextrin-Threaded Polyrotaxanes by Conjugating Cyclic RGD Peptides

Enhanced Tumor Targeting and Antitumor Activity of Methylated β-Cyclodextrin-Threaded Polyrotaxanes by Conjugating Cyclic RGD Peptides

We previously reported that acid-degradable methylated β-cyclodextrins (Me-β-CDs)-threaded polyrotaxanes (Me-PRXs) can induce autophagic cell death through endoplasmic reticulum (ER) stress-related autophagy, even in apoptosis-resistant cells. Hence, Me-PRXs show great potential as anticancer therap...

Full description

Bibliographic Details
Main Authors: Shunyao Zhang, Atsushi Tamura, Nobuhiko Yui
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biomolecules
Subjects:
polyrotaxane
methylated β-cyclodextrin
cyclic RGD peptide
antitumor activity
tumor targeting
Online Access:https://www.mdpi.com/2218-273X/14/2/223

Internet

https://www.mdpi.com/2218-273X/14/2/223

Similar Items