Enhanced Tumor Targeting and Antitumor Activity of Methylated β-Cyclodextrin-Threaded Polyrotaxanes by Conjugating Cyclic RGD Peptides

Enhanced Tumor Targeting and Antitumor Activity of Methylated β-Cyclodextrin-Threaded Polyrotaxanes by Conjugating Cyclic RGD Peptides

We previously reported that acid-degradable methylated β-cyclodextrins (Me-β-CDs)-threaded polyrotaxanes (Me-PRXs) can induce autophagic cell death through endoplasmic reticulum (ER) stress-related autophagy, even in apoptosis-resistant cells. Hence, Me-PRXs show great potential as anticancer therap...

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Bibliografski detalji
Glavni autori: Shunyao Zhang, Atsushi Tamura, Nobuhiko Yui
Format: Članak
Jezik:English
Izdano: MDPI AG 2024-02-01
Serija:Biomolecules
Teme:
polyrotaxane
methylated β-cyclodextrin
cyclic RGD peptide
antitumor activity
tumor targeting
Online pristup:https://www.mdpi.com/2218-273X/14/2/223

Internet

https://www.mdpi.com/2218-273X/14/2/223

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