YME1L-mediated mitophagy protects renal tubular cells against cellular senescence under diabetic conditions

Abstract Background The senescence of renal tubular epithelial cells (RTECs) is crucial in the progression of diabetic kidney disease (DKD). Accumulating evidence suggests a close association between insufficient mitophagy and RTEC senescence. Yeast mitochondrial escape 1-like 1 (YME1L), an inner mi...

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Bibliographic Details
Main Authors: Yuanyuan Luo, Lingxiao Zhang, Ning Su, Lerong Liu, Tongfeng Zhao
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Biological Research
Subjects:
Online Access:https://doi.org/10.1186/s40659-024-00487-0