Inhibition of Netosis with PAD Inhibitor Attenuates Endotoxin Shock Induced Systemic Inflammation

Inhibition of Netosis with PAD Inhibitor Attenuates Endotoxin Shock Induced Systemic Inflammation

Neutrophils play a pivotal role in innate immunity by releasing neutrophils extracellular traps (NETs). Excessive NETs are detrimental to the local tissue and further exacerbate inflammation. Protein arginine deiminases (PAD) mediate histone citrullination and NET formation that, in turn, exacerbate...

Full description

Bibliographic Details
Main Authors: Huanling Yao, Guojie Cao, Zheng Liu, Yue Zhao, Zhanchao Yan, Senzhen Wang, Yuehua Wang, Zhengwei Guo, Yanming Wang
Format: Article
Language:English
Published: MDPI AG 2022-10-01
Series:International Journal of Molecular Sciences
Subjects:
PAD inhibitor
endotoxin shock
netosis
systemic inflammation
LPS
RNA-seq
Online Access:https://www.mdpi.com/1422-0067/23/21/13264

Internet

https://www.mdpi.com/1422-0067/23/21/13264

Similar Items