Passaging Primary Human Bronchial Epithelia Reduces CFTR-Mediated Fluid Transport and Alters mRNA Expression

Passaging Primary Human Bronchial Epithelia Reduces CFTR-Mediated Fluid Transport and Alters mRNA Expression

Primary human bronchial epithelial cultures (HBECs) are used to study airway physiology, disease, and drug development. HBECs often replicate human airway physiology/pathophysiology. Indeed, in the search for cystic fibrosis (CF) transmembrane conductance regulator (CFTR) therapies, HBECs were seen...

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Autors principals:	Tongde Wu, Joe A. Wrennall, Hong Dang, Deborah L. Baines, Robert Tarran
Format:	Article
Idioma:	English
Publicat:	MDPI AG 2023-03-01
Col·lecció:	Cells
Matèries:	airway surface liquid tight junction membrane transport Ussing chamber water permeability
Accés en línia:	https://www.mdpi.com/2073-4409/12/7/997

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