Passaging Primary Human Bronchial Epithelia Reduces CFTR-Mediated Fluid Transport and Alters mRNA Expression

Passaging Primary Human Bronchial Epithelia Reduces CFTR-Mediated Fluid Transport and Alters mRNA Expression

Primary human bronchial epithelial cultures (HBECs) are used to study airway physiology, disease, and drug development. HBECs often replicate human airway physiology/pathophysiology. Indeed, in the search for cystic fibrosis (CF) transmembrane conductance regulator (CFTR) therapies, HBECs were seen...

Ausführliche Beschreibung

Bibliographische Detailangaben
Hauptverfasser: Tongde Wu, Joe A. Wrennall, Hong Dang, Deborah L. Baines, Robert Tarran
Format: Artikel
Sprache:English
Veröffentlicht: MDPI AG 2023-03-01
Schriftenreihe:Cells
Schlagworte:
airway surface liquid
tight junction
membrane transport
Ussing chamber
water permeability
Online Zugang:https://www.mdpi.com/2073-4409/12/7/997

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