OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development

OBSCN undergoes extensive alternative splicing during human cardiac and skeletal muscle development

Abstract Background Highly expressed in skeletal muscles, the gene Obscurin (i.e. OBSCN) has 121 non-overlapping exons and codes for some of the largest known mRNAs in the human genome. Furthermore, it plays an essential role in muscle development and function. Mutations in OBSCN are associated with...

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Bibliographic Details
Main Authors: Ali Oghabian, Per Harald Jonson, Swethaa Natraj Gayathri, Mridul Johari, Ella Nippala, David Gomez Andres, Francina Munell, Jessica Camacho Soriano, Maria Angeles Sanchez Duran, Juha Sinisalo, Heli Tolppanen, Johanna Tolva, Peter Hackman, Marco Savarese, Bjarne Udd
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Skeletal Muscle
Subjects:
Neuromuscular diseases
OBSCN/RNA splicing
Exon inclusion
Muscle development
Online Access:https://doi.org/10.1186/s13395-025-00374-6

Internet

https://doi.org/10.1186/s13395-025-00374-6

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