Insights into an NEk2 inhibitory profile of nitidine chloride by molecular docking and biological evaluation

Insights into an NEk2 inhibitory profile of nitidine chloride by molecular docking and biological evaluation

Abstract Deregulation of NEK2(NIMA-related serine/threonine 2) confers chemotherapeutic resistance to apoptosis and is closely correlated with poor prognosis in hepatocellular carcinoma (HCC). Here, we find that nanoparticles are prepared through hemisynthesis from natural nitidine chloride (NC) wit...

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Bibliographic Details
Main Authors: Danni Li, Jiahao Lu, Qiying Zhang, Yuzhu Zhou, Long Li, Hua Zhu, Tong Li
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Chemistry
Subjects:
Nitidine chloride nanoparticle
Li-7 hepatocellular carcinoma cells
Nitidine chloride
MOE molecular docking
NEK2 protein
Online Access:https://doi.org/10.1186/s13065-022-00870-6

Internet

https://doi.org/10.1186/s13065-022-00870-6

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