Alteration of Gut Microbiome and Correlated Amino Acid Metabolism Contribute to Hyperuricemia and Th17-Driven Inflammation in Uox-KO Mice

Alteration of Gut Microbiome and Correlated Amino Acid Metabolism Contribute to Hyperuricemia and Th17-Driven Inflammation in Uox-KO Mice

Although gut dysbiosis had been demonstrated to be an important factor affecting hyperuricemia (HUA) and gout, little is known for its potential mechanistic connections. In this study, Uox-KO mice model that with spontaneously developed pronounced HUA and urate nephropathy was used to explore the pa...

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Bibliographic Details
Main Authors: Siyue Song, Yu Lou, Yingying Mao, Xianghui Wen, Moqi Fan, Zhixing He, Yang Shen, Chengping Wen, Tiejuan Shao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Immunology
Subjects:
gut microbiota
hyperuricemia (HUA)
Gout
amino acid metabolism
T cell immunity
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.804306/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.804306/full

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