The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα

The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα

Abstract Background Peroxisome proliferator-activated receptor gamma (PPARγ) is an enhancer of Treg responses, but the mechanisms remain elusive. This study aimed to solve this problem in view of cellular metabolism. Methods Three recognized PPARγ agonists (synthetic agonist: rosiglitazone; endogeno...

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Bibliographic Details
Main Authors: Yumeng Miao, Changliu Zhang, Ling Yang, Xi Zeng, Yuxiao Hu, Xinru Xue, Yue Dai, Zhifeng Wei
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Cell Communication and Signaling
Subjects:
PPARγ
Treg responses
CD36/CPT1
Fatty acid oxidation
UDP-GlcNAc/glycosylation
Online Access:https://doi.org/10.1186/s12964-022-00849-9

Internet

https://doi.org/10.1186/s12964-022-00849-9

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