Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives

Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives

Abstract We have synthesized new series of bisindole analogs (1–27), characterized by 1HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC50 values ranging from 0.7 ± 0.01 to 13.30 ± 0.50 µM respectively when compared wi...

Full description

Bibliographic Details
Main Authors: Muhammad Taha, Imad Uddin, Mohammed Gollapalli, Noor Barak Almandil, Fazal Rahim, Rai Khalid Farooq, Muhammad Nawaz, Mohamed Ibrahim, Mohammed A. Alqahtani, Yasser A. Bamarouf, Manikandan Selvaraj
Format: Article
Language:English
Published: BMC 2019-08-01
Series:BMC Chemistry
Subjects:
Synthesis
Bisindole
Leishmaniasis
Molecular docking
SAR
Online Access:http://link.springer.com/article/10.1186/s13065-019-0617-4

Internet

http://link.springer.com/article/10.1186/s13065-019-0617-4

Similar Items