Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia

Therapeutic targeting of mutant p53 in pediatric acute lymphoblastic leukemia

Alterations of the tumor suppressor gene TP53 are found in different cancers, in particular in carcinomas of adults. In pediatric acute lymphoblastic leukemia (ALL), TP53 mutations are infrequent but enriched at relapse. As in most cancers, mainly DNA-binding domain missense mutations are found, res...

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Bibliographic Details
Main Authors: Salih Demir, Elena Boldrin, Qian Sun, Stephanie Hampp, Eugen Tausch, Cornelia Eckert, Martin Ebinger, Rupert Handgretinger, Geertruy te Kronnie, Lisa Wiesmüller, Stephan Stilgenbauer, Galina Selivanova, Klaus-Michael Debatin, Lüder Hinrich Meyer
Format: Article
Language:English
Published: Ferrata Storti Foundation 2020-01-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/9486

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https://haematologica.org/article/view/9486

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