Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models

Autotaxin inhibitor IOA-289 reduces gastrointestinal cancer progression in preclinical models

Abstract Background Autotaxin (ATX) is a secreted enzyme that converts lysophosphatidylcholine to lysophosphatidic acid (LPA). LPA stimulates cell proliferation and migration and promotes wound repair following tissue damage. ATX levels are directly correlated with stage and grade in several human c...

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Bibliographic Details
Main Authors: Matteo Centonze, Giusy Di Conza, Michael Lahn, Isabel Fabregat, Francesco Dituri, Isabella Gigante, Grazia Serino, Rosanna Scialpi, Livianna Carrieri, Roberto Negro, Elena Pizzuto, Gianluigi Giannelli
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Autotaxin
Lysophosphatidic acid
Gastrointestinal cancers
Online Access:https://doi.org/10.1186/s13046-023-02780-4

Internet

https://doi.org/10.1186/s13046-023-02780-4

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