TGF-β1–induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation?
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, with an unmet therapeutic need. Fibrotic remodeling, in which collagen-producing atrial fibroblasts play a crucial role, substantially contributes to arrhythmia promotion and progression. In this issue of the JCI, Lai, Tsai, a...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
American Society for Clinical Investigation
2022-07-01
|
| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI161070 |
| _version_ | 1828204565741174784 |
|---|---|
| author | Arnela Saljic Eleonora Grandi Dobromir Dobrev |
| author_facet | Arnela Saljic Eleonora Grandi Dobromir Dobrev |
| author_sort | Arnela Saljic |
| collection | DOAJ |
| description | Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, with an unmet therapeutic need. Fibrotic remodeling, in which collagen-producing atrial fibroblasts play a crucial role, substantially contributes to arrhythmia promotion and progression. In this issue of the JCI, Lai, Tsai, and co-authors reveal that TGF-β1 promoted endothelial-mesenchymal transition during AF and put forward the notion that, in the adult heart, atrial fibroblasts can originate from different cellular sources. These important findings extend our understanding of the origin, biology, and function of fibroblasts and offer possibilities for therapeutic targeting of fibrosis in AF. |
| first_indexed | 2024-04-12T12:25:47Z |
| format | Article |
| id | doaj.art-bc621f7b4af44821a1931fbc9b91b005 |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-04-12T12:25:47Z |
| publishDate | 2022-07-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-bc621f7b4af44821a1931fbc9b91b0052022-12-22T03:33:11ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382022-07-0113213TGF-β1–induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation?Arnela SaljicEleonora GrandiDobromir DobrevAtrial fibrillation (AF) is the most common cardiac arrhythmia worldwide, with an unmet therapeutic need. Fibrotic remodeling, in which collagen-producing atrial fibroblasts play a crucial role, substantially contributes to arrhythmia promotion and progression. In this issue of the JCI, Lai, Tsai, and co-authors reveal that TGF-β1 promoted endothelial-mesenchymal transition during AF and put forward the notion that, in the adult heart, atrial fibroblasts can originate from different cellular sources. These important findings extend our understanding of the origin, biology, and function of fibroblasts and offer possibilities for therapeutic targeting of fibrosis in AF.https://doi.org/10.1172/JCI161070 |
| spellingShingle | Arnela Saljic Eleonora Grandi Dobromir Dobrev TGF-β1–induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation? The Journal of Clinical Investigation |
| title | TGF-β1–induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation? |
| title_full | TGF-β1–induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation? |
| title_fullStr | TGF-β1–induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation? |
| title_full_unstemmed | TGF-β1–induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation? |
| title_short | TGF-β1–induced endothelial-mesenchymal transition: a potential contributor to fibrotic remodeling in atrial fibrillation? |
| title_sort | tgf β1 induced endothelial mesenchymal transition a potential contributor to fibrotic remodeling in atrial fibrillation |
| url | https://doi.org/10.1172/JCI161070 |
| work_keys_str_mv | AT arnelasaljic tgfb1inducedendothelialmesenchymaltransitionapotentialcontributortofibroticremodelinginatrialfibrillation AT eleonoragrandi tgfb1inducedendothelialmesenchymaltransitionapotentialcontributortofibroticremodelinginatrialfibrillation AT dobromirdobrev tgfb1inducedendothelialmesenchymaltransitionapotentialcontributortofibroticremodelinginatrialfibrillation |