IL-1-IL-17 Signaling Axis Contributes to Fibrosis and Inflammation in Two Different Murine Models of Systemic Sclerosis

IL-1-IL-17 Signaling Axis Contributes to Fibrosis and Inflammation in Two Different Murine Models of Systemic Sclerosis

ObjectiveSystemic sclerosis (SSc) is a progressive fibrotic disease that affects the skin and internal organs. Despite evidence implicating increased interleukin-17 (IL-17) activity in SSc, the role of IL-17 in SSc remains uncertain. The purpose of this study was to investigate whether IL-17 plays a...

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Bibliographic Details
Main Authors: Min-Jung Park, Su-Jin Moon, Eun-Jung Lee, Kyung-Ah Jung, Eun-Kyung Kim, Da-Som Kim, Jung-Ho Lee, Seung-Ki Kwok, Jun-Ki Min, Sung-Hwan Park, Mi-La Cho
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Immunology
Subjects:
systemic sclerosis
skin fibrosis
lung fibrosis
interleukin-17
interleukin-1
chronic graft-versus-host disease
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.01611/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.01611/full

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