Oxygen-Dependent Accumulation of Purine DNA Lesions in Cockayne Syndrome Cells

Oxygen-Dependent Accumulation of Purine DNA Lesions in Cockayne Syndrome Cells

Cockayne Syndrome (CS) is an autosomal recessive neurodegenerative premature aging disorder associated with defects in nucleotide excision repair (NER). Cells from CS patients, with mutations in <i>CSA</i> or <i>CSB</i> genes, present elevated levels of reactive oxygen specie...

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Bibliographic Details
Main Authors: Marios G. Krokidis, Mariarosaria D’Errico, Barbara Pascucci, Eleonora Parlanti, Annalisa Masi, Carla Ferreri, Chryssostomos Chatgilialoglu
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Cells
Subjects:
CSA
CSB
oxygen concentration
free radicals
oxidatively generated DNA damage
isotope dilution LC-MS/MS
Online Access:https://www.mdpi.com/2073-4409/9/7/1671

Internet

https://www.mdpi.com/2073-4409/9/7/1671

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