Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.

Upregulation of miR21 and repression of Grhl3 by leptin mediates sinusoidal endothelial injury in experimental nonalcoholic steatohepatitis.

Sinusoidal endothelial dysfunction (SED) has been found to be an early event in nonalcoholic steatohepatitis (NASH) progression but the molecular mechanisms underlying its causation remains elusive. We hypothesized that adipokine leptin worsens sinusoidal injury by decreasing functionally active nit...

Full description

Bibliographic Details
Main Authors: Sahar Pourhoseini, Ratanesh Kumar Seth, Suvarthi Das, Diptadip Dattaroy, Maria B Kadiiska, Guanhua Xie, Gregory A Michelotti, Mitzi Nagarkatti, Anna Mae Diehl, Saurabh Chatterjee
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4319738?pdf=render

Internet

http://europepmc.org/articles/PMC4319738?pdf=render

Similar Items