PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis

PD-1 signaling uncovers a pathogenic subset of T cells in inflammatory arthritis

Abstract Background PD-1 is an immune checkpoint on T cells, and interventions to block this receptor result in T cell activation and enhanced immune response to tumors and pathogens. Reciprocally, despite a decade of research, approaches to treat autoimmunity with PD-1 agonists have only had limite...

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Bibliographic Details
Main Authors: Johanna Straube, Shoiab Bukhari, Shalom Lerrer, Robert J. Winchester, Yevgeniya Gartshteyn, Brian S. Henick, Matthew A. Dragovich, Adam Mor
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Arthritis Research & Therapy
Subjects:
Inflammatory arthritis
Synovial fluid
T cells
KLRG1
PD-1 agonist
Online Access:https://doi.org/10.1186/s13075-023-03259-5

Internet

https://doi.org/10.1186/s13075-023-03259-5

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