Activity of Birinapant, a SMAC Mimetic Compound, Alone or in Combination in NSCLCs With Different Mutations

Activity of Birinapant, a SMAC Mimetic Compound, Alone or in Combination in NSCLCs With Different Mutations

Liver kinase B1 (LKB1/STK11) is the second tumor suppressor gene most frequently mutated in non-small-cell lung cancer (NSCLC) and its activity is impaired in about half KRAS-mutated NSCLCs. Nowadays, no effective therapies are available for patients having these mutations. To highlight new vulnerab...

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Bibliographic Details
Main Authors: Marika Colombo, Mirko Marabese, Giulia Vargiu, Massimo Broggini, Elisa Caiola
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Oncology
Subjects:
non-small-cell lung cancer
liver kinase B1
KRAS
drug library in vitro screening
SMAC mimetic compounds
3D culture (three-dimensional spheroids)
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2020.532292/full

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https://www.frontiersin.org/articles/10.3389/fonc.2020.532292/full

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