Mechanisms of Metal-Induced Mitochondrial Dysfunction in Neurological Disorders

Metals are actively involved in multiple catalytic physiological activities. However, metal overload may result in neurotoxicity as it increases formation of reactive oxygen species (ROS) and elevates oxidative stress in the nervous system. Mitochondria are a key target of metal-induced toxicity, gi...

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Bibliographic Details
Main Authors: Hong Cheng, Bobo Yang, Tao Ke, Shaojun Li, Xiaobo Yang, Michael Aschner, Pan Chen
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Toxics
Subjects:
Online Access:https://www.mdpi.com/2305-6304/9/6/142