AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes

AMPK activator decelerates osteoarthritis development by inhibition of β-catenin signaling in chondrocytes

Background: Osteoarthritis (OA) is a common degenerative joint disease with significant negative impact on the quality of life. It has been reported that abnormal upregulation of β-catenin signaling could lead to OA development; however, the upstream regulatory mechanisms of β-catenin signaling have...

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Bibliographic Details
Main Authors: Zhenglin Zhu, Yanran Huang, Jun Li, Dan Yi, Junyi Liao, Jun Xiao, Guozhi Xiao, Liping Tong, Wei Huang, Chen Di
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Journal of Orthopaedic Translation
Subjects:
Osteoarthritis
AMPK
β-catenin
Phosphorylation
Metformin
Chondrocyte
Online Access:http://www.sciencedirect.com/science/article/pii/S2214031X2200105X

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http://www.sciencedirect.com/science/article/pii/S2214031X2200105X

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