DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling

DLX5 regulates the osteogenic differentiation of spinal ligaments cells derived from ossification of the posterior longitudinal ligament patients via NOTCH signaling

Abstract Background Ossification of the posterior longitudinal ligaments (OPLL) is common disorder characterized by heterotopic ossification of the spinal ligaments. Mechanical stimulation (MS) plays an important role in OPLL. DLX5 is an essential transcription factor required for osteoblast differe...

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Bibliographic Details
Main Authors: Tao Tang, Zhengya Zhu, Zhongyuan He, Fuan Wang, Hongkun Chen, Shengkai Liu, Mingbin Zhan, Jianmin Wang, Wei Tian, Dafu Chen, Xinbao Wu, Xizhe Liu, Zhiyu Zhou, Shaoyu Liu
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:JOR Spine
Subjects:
cyclic stretch
DLX5
mechanical stimulation
NOTCH signaling
OPLL
osteogenic differentiation
Online Access:https://doi.org/10.1002/jsp2.1247

Internet

https://doi.org/10.1002/jsp2.1247

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