Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer

Metabolic synthetic lethality by targeting NOP56 and mTOR in KRAS-mutant lung cancer

Abstract Background Oncogenic KRAS mutations are prevalent in human cancers, but effective treatment of KRAS-mutant malignancies remains a major challenge in the clinic. Increasing evidence suggests that aberrant metabolism plays a central role in KRAS-driven oncogenic transformation. The aim of thi...

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Bibliographic Details
Main Authors: Zhang Yang, Shun-Qing Liang, Liang Zhao, Haitang Yang, Thomas M. Marti, Balazs Hegedüs, Yanyun Gao, Bin Zheng, Chun Chen, Wenxiang Wang, Patrick Dorn, Gregor J. Kocher, Ralph A. Schmid, Ren-Wang Peng
Format: Article
Language:English
Published: BMC 2022-01-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
KRAS-mutant cancer
NOP56
mTOR
ROS
Synthetic lethal vulnerability
Online Access:https://doi.org/10.1186/s13046-022-02240-5

Internet

https://doi.org/10.1186/s13046-022-02240-5

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