Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly

Mechanoregulated inhibition of formin facilitates contractile actomyosin ring assembly

The fission yeast cytokinetic ring assembles by Search-Capture-Pull-Release from precursor nodes that include formin Cdc12 and myosin Myo2. The authors reconstitute Search-Capture-Pull in vitro and find that Myo2 pulling on Cdc12-associated actin filaments mechano-inhibits Cdc12-mediated assembly, w...

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Bibliographic Details
Main Authors: Dennis Zimmermann, Kaitlin E. Homa, Glen M. Hocky, Luther W. Pollard, Enrique M. De La Cruz, Gregory A. Voth, Kathleen M. Trybus, David R. Kovar
Format: Article
Language:English
Published: Nature Portfolio 2017-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00445-3

Internet

https://doi.org/10.1038/s41467-017-00445-3

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