In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity

In vivo tumor surveillance by NK cells requires TYK2 but not TYK2 kinase activity

Tyrosine kinase 2 (TYK2) is a Janus kinase (JAK) that is crucially involved in inflammation, carcinogenesis and defense against infection. The cytotoxic activity of natural killer (NK) cells in TYK2-deficient (Tyk2−/−) mice is severely reduced, although the underlying mechanisms are largely unknown....

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Bibliographic Details
Main Authors: Michaela Prchal-Murphy, Agnieszka Witalisz-Siepracka, Karoline T Bednarik, Eva Maria Putz, Dagmar Gotthardt, Katrin Meissl, Veronika Sexl, Mathias Müller, Birgit Strobl
Format: Article
Language:English
Published: Taylor & Francis Group 2015-11-01
Series:OncoImmunology
Subjects:
interferon γ
interleukin-12
NK cells
tumor surveillance
tyrosine kinase 2
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2015.1047579

Internet

https://www.tandfonline.com/doi/10.1080/2162402X.2015.1047579

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