MicroRNA-138-5p Targets Pro-Apoptotic Factors and Favors Neural Cell Survival: Analysis in the Injured Spinal Cord

The central nervous system microRNA miR-138-5p has attracted much attention in cancer research because it inhibits pro-apoptotic genes including CASP3. We hypothesize that miR-138-5p downregulation after SCI leads to overexpression of pro-apoptotic genes, sensitizing neural cells to noxious stimuli....

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Bibliographic Details
Main Authors: Rodrigo M. Maza, María Asunción Barreda-Manso, David Reigada, Ágata Silván, Teresa Muñoz-Galdeano, Altea Soto, Ángela del Águila, Manuel Nieto-Díaz
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Biomedicines
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Online Access:https://www.mdpi.com/2227-9059/10/7/1559