LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells

LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells

Abstract Background The benefits of first-line, cisplatin-based chemotherapy for muscle-invasive bladder cancer are limited due to intrinsic or acquired resistance to cisplatin. Increasing evidence has revealed the implication of cancer stem cells in the development of chemoresistance. However, the...

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Bibliographic Details
Main Authors: Hongjin Shi, Zhiyong Tan, Bowen Duan, Chunming Guo, Chong Li, Ting Luan, Ning Li, Yinglong Huang, Shi Chen, Jixian Gao, Wei Feng, Haole Xu, Jiansong Wang, Shi Fu, Haifeng Wang
Format: Article
Language:English
Published: BMC 2024-01-01
Series:BMC Medicine
Subjects:
Bladder cancer
Cancer stem cell
Drug resistance
Ceramide
Cisplatin sensitivity
β-catenin
Online Access:https://doi.org/10.1186/s12916-023-03243-5

Internet

https://doi.org/10.1186/s12916-023-03243-5

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