LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells

LASS2 enhances chemosensitivity to cisplatin by inhibiting PP2A-mediated β-catenin dephosphorylation in a subset of stem-like bladder cancer cells

Abstract Background The benefits of first-line, cisplatin-based chemotherapy for muscle-invasive bladder cancer are limited due to intrinsic or acquired resistance to cisplatin. Increasing evidence has revealed the implication of cancer stem cells in the development of chemoresistance. However, the...

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Podrobná bibliografie
Hlavní autoři: Hongjin Shi, Zhiyong Tan, Bowen Duan, Chunming Guo, Chong Li, Ting Luan, Ning Li, Yinglong Huang, Shi Chen, Jixian Gao, Wei Feng, Haole Xu, Jiansong Wang, Shi Fu, Haifeng Wang
Médium: Článek
Jazyk:English
Vydáno: BMC 2024-01-01
Edice:BMC Medicine
Témata:
Bladder cancer
Cancer stem cell
Drug resistance
Ceramide
Cisplatin sensitivity
β-catenin
On-line přístup:https://doi.org/10.1186/s12916-023-03243-5

Internet

https://doi.org/10.1186/s12916-023-03243-5

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