Transcriptional inhibition of STAT1 functions in the nucleus alleviates Th1 and Th17 cell-mediated inflammatory diseases

Transcriptional inhibition of STAT1 functions in the nucleus alleviates Th1 and Th17 cell-mediated inflammatory diseases

T helper 1 cells (Th1 cells) and T helper 17 cells (Th17 cells) play pivotal roles in the pathogenesis of various autoimmune diseases, including psoriasis and inflammatory bowel disease (IBD). Signal transducer and activator of transcription 1 (STAT1) regulates the Th1 and Th17 cell lineage commitme...

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Bibliographic Details
Main Authors: Jiyoon Park, Min-Ji Son, Chun-Chang Ho, Su-Hyeon Lee, Yuna Kim, Jaekyeung An, Sang-Kyou Lee
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
signal transducer and activator of transcription 1 (STAT1)
Th1 cells
Th17 cells
psoriasis
inflammatory bowel disease (IBD)
transcription modulation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1054472/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1054472/full

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