Transcriptional inhibition of STAT1 functions in the nucleus alleviates Th1 and Th17 cell-mediated inflammatory diseases

Transcriptional inhibition of STAT1 functions in the nucleus alleviates Th1 and Th17 cell-mediated inflammatory diseases

T helper 1 cells (Th1 cells) and T helper 17 cells (Th17 cells) play pivotal roles in the pathogenesis of various autoimmune diseases, including psoriasis and inflammatory bowel disease (IBD). Signal transducer and activator of transcription 1 (STAT1) regulates the Th1 and Th17 cell lineage commitme...

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Bibliographic Details
Main Authors:	Jiyoon Park, Min-Ji Son, Chun-Chang Ho, Su-Hyeon Lee, Yuna Kim, Jaekyeung An, Sang-Kyou Lee
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-12-01
Series:	Frontiers in Immunology
Subjects:	signal transducer and activator of transcription 1 (STAT1) Th1 cells Th17 cells psoriasis inflammatory bowel disease (IBD) transcription modulation
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1054472/full

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