Individualized treatment based on single-nucleotide polymorphisms with tacrolimus in ulcerative colitis

Individualized treatment based on single-nucleotide polymorphisms with tacrolimus in ulcerative colitis

Background/Aims The pharmacokinetics of tacrolimus (TAC) is known to be largely influenced by single-nucleotide polymorphisms (SNPs) in CYP3A5. Patients starting TAC require careful dose adjustment, owing to the wide range of optimal dosages, depending on their CYP3A5 expression status. Here, we eva...

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Bibliographic Details
Main Authors: Shinji Okabayashi, Taku Kobayashi, Eiko Saito, Takahiko Toyonaga, Ryo Ozaki, Shintaro Sagami, Masaru Nakano, Junichi Tanaka, Keiji Yagisawa, Satoshi Kuronuma, Osamu Takeuchi, Toshifumi Hibi
Format: Article
Language:English
Published: Korean Association for the Study of Intestinal Diseases 2019-04-01
Series:Intestinal Research
Subjects:
Colitis, ulcerative
Tacrolimus
Individualized treatment
Online Access:http://www.irjournal.org/upload/pdf/ir-2018-00117.pdf

Internet

http://www.irjournal.org/upload/pdf/ir-2018-00117.pdf

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