In Vitro Transcribed mRNA Immunogenicity Induces Chemokine‐Mediated Lymphocyte Recruitment and Can Be Gradually Tailored by Uridine Modification

In Vitro Transcribed mRNA Immunogenicity Induces Chemokine‐Mediated Lymphocyte Recruitment and Can Be Gradually Tailored by Uridine Modification

Abstract Beyond SARS‐CoV2 vaccines, mRNA drugs are being explored to overcome today's greatest healthcare burdens, including cancer and cardiovascular disease. Synthetic mRNA triggers immune responses in transfected cells, which can be reduced by chemically modified nucleotides. However, the si...

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Bibliographic Details
Main Authors: Norman M. Drzeniek, Nourhan Kahwaji, Samira Picht, Ioanna Maria Dimitriou, Stephan Schlickeiser, Hanieh Moradian, Sven Geissler, Michael Schmueck‐Henneresse, Manfred Gossen, Hans‐Dieter Volk
Format: Article
Language:English
Published: Wiley 2024-06-01
Series:Advanced Science
Subjects:
5‐methoxyuridine
CXCL10
immunoengineering
innate immune activation
N1‐methylpseudouridine
nucleoside‐modified messenger RNA
Online Access:https://doi.org/10.1002/advs.202308447

Internet

https://doi.org/10.1002/advs.202308447

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