Long trimer-immunization interval and appropriate adjuvant reduce immune responses to the soluble HIV-1-envelope trimer base

Long trimer-immunization interval and appropriate adjuvant reduce immune responses to the soluble HIV-1-envelope trimer base

Summary: Soluble ‘SOSIP’-stabilized HIV-1 envelope glycoprotein (Env) trimers elicit dominant antibody responses targeting their glycan-free base regions, potentially diminishing neutralizing responses. Previously, using a nonhuman primate model, we demonstrated that priming with fusion peptide (FP)...

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Bibliographic Details
Main Authors: Hongying Duan, Angela R. Corrigan, Cheng Cheng, Andrea Biju, Christopher A. Gonelli, Adam S. Olia, I-Ting Teng, Kai Xu, Sijy O’Dell, Sandeep Narpala, Mike Castro, Leonid Serebryannyy, Jennifer Wang, Danealle K. Parchment, Edward K. Sarfo, Jelle van Schooten, John-Paul Todd, Shuishu Wang, Darcy R. Harris, Hui Geng, Alexander J. Jafari, Ruth A. Woodward, Nicole A. Doria-Rose, Kathryn E. Foulds, Adrian B. McDermott, Marit J. van Gils, Richard A. Koup, Theodore C. Pierson, Peter D. Kwong, John R. Mascola
Format: Article
Language:English
Published: Elsevier 2024-02-01
Series:iScience
Subjects:
Immune response
Virology
Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004224000981

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http://www.sciencedirect.com/science/article/pii/S2589004224000981

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