Androgen Receptor-CaMKK2 Axis in Prostate Cancer and Bone Microenvironment

Androgen Receptor-CaMKK2 Axis in Prostate Cancer and Bone Microenvironment

The skeletal system is of paramount importance in advanced stage prostate cancer (PCa) as it is the preferred site of metastasis. Complex mechanisms are employed sequentially by PCa cells to home to and colonize the bone. Bone-resident PCa cells then recruit osteoblasts (OBs), osteoclasts (OCs), and...

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Bibliographic Details
Main Authors: Ushashi C. Dadwal, Eric S. Chang, Uma Sankar
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-06-01
Series:Frontiers in Endocrinology
Subjects:
castrate-resistant prostate cancer
androgen-deprivation therapy
CAMKK2
bone–tumor microenvironment
treatment induced bone loss
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00335/full

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https://www.frontiersin.org/article/10.3389/fendo.2018.00335/full

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