Genetic variation in histone modifications and gene expression identifies regulatory variants in the mammary gland of cattle

Genetic variation in histone modifications and gene expression identifies regulatory variants in the mammary gland of cattle

Abstract Background Causal variants for complex traits, such as eQTL are often found in non-coding regions of the genome, where they are hypothesised to influence phenotypes by regulating gene expression. Many regulatory regions are marked by histone modifications, which can be assayed by chromatin...

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Bibliographic Details
Main Authors: Claire P. Prowse-Wilkins, Thomas J. Lopdell, Ruidong Xiang, Christy J. Vander Jagt, Mathew D. Littlejohn, Amanda J. Chamberlain, Michael E. Goddard
Format: Article
Language:English
Published: BMC 2022-12-01
Series:BMC Genomics
Subjects:
bovine
ChIP-seq
histone modifications
function
causal variants
allele specific QTL
Online Access:https://doi.org/10.1186/s12864-022-09002-9

Internet

https://doi.org/10.1186/s12864-022-09002-9

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