Dynamic expansion of mesenchymal stem/stromal cells in a stirred tank bioreactor promotes the release of potent extracellular vesicles

Dynamic expansion of mesenchymal stem/stromal cells in a stirred tank bioreactor promotes the release of potent extracellular vesicles

Mesenchymal stem/stromal cell-derived extracellular vesicles (MSC-EVs) are considered a promising therapeutic tool in cell therapy due to their immunomodulatory, regenerative and angiogenic capabilities. However, there is a lack of process knowledge, particularly for a large-scale production of MSC-...

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Bibliographic Details
Main Authors: Jan Barekzai, Jonas Friedrich, Maduwuike Okpara, Laura Refflinghaus, Dustin Eckhardt, Peter Czermak, Denise Salzig
Format: Article
Language:English
Published: AIMS Press 2023-09-01
Series:AIMS Bioengineering
Subjects:
potent ev production
microcarrier-based process
large-scale msc-ev production
scratch assay
ev analysis
Online Access:https://www.aimspress.com/article/doi/10.3934/bioeng.2023016?viewType=HTML

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https://www.aimspress.com/article/doi/10.3934/bioeng.2023016?viewType=HTML

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