Effects of Methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to an open-space spatial maze

Effects of Methimepip and JNJ-5207852 in Wistar rats exposed to an open-field with and without object and in Balb/c mice exposed to an open-space spatial maze

The role of the histamine H3 receptor in anxiety is controversial, due to limitations in drug selectivity and limited validity of behavioral tests in previous studies. When exposed to an empty open field, Wistar rats spent more time in the outer area and made very low number of brief crossings in th...

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Bibliographic Details
Main Authors: Abdel eEnnaceur, Rushdie M.A. ABUHAMDAH, Natasha L Lethbridge, Paul L Chazot, Ruan evan Rensburg
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-07-01
Series:Frontiers in Systems Neuroscience
Subjects:
Anxiety
Fear
Histamine
3D maze
avoidance
Object novelty
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00054/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnsys.2012.00054/full

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