Epigenetic reshaping through damage: promoting cell fate transition by BrdU and IdU incorporation

Abstract Background Thymidine analogs have long been recognized for their ability to randomly incorporate into DNA. However, the precise mechanisms through which thymidine analogs facilitate cell fate transition remains unclear. Results Here, we discovered a strong correlation between the dosage dep...

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Bibliographic Details
Main Authors: Chuang Li, Xiaoduo Xu, Shuyan Chen, Anchun Xu, Tongxing Guan, Haokaifeng Wu, Duanqing Pei, Jing Liu
Format: Article
Language:English
Published: BMC 2024-01-01
Series:Cell & Bioscience
Online Access:https://doi.org/10.1186/s13578-024-01192-x