Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer’s Disease

Age-Dependent and Aβ-Induced Dynamic Changes in the Subcellular Localization of HMGB1 in Neurons and Microglia in the Brains of an Animal Model of Alzheimer’s Disease

HMGB1 is a prototypical danger-associated molecular pattern (DAMP) molecule that co-localizes with amyloid beta (Aβ) in the brains of patients with Alzheimer’s disease. HMGB1 levels are significantly higher in the cerebrospinal fluid of patients. However, the cellular and subcellular distribution of...

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Bibliographic Details
Main Authors: Song-I Seol, Dashdulam Davaanyam, Sang-A Oh, Eun-Hwa Lee, Pyung-Lim Han, Seung-Woo Kim, Ja-Kyeong Lee
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Cells
Subjects:
HMGB1
AD
Aβ
frontal cortex
aging
Online Access:https://www.mdpi.com/2073-4409/13/2/189

Internet

https://www.mdpi.com/2073-4409/13/2/189

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